Digital endpoints for therapeutics: turning subjective assessment into functional data
We help therapeutics teams build digital endpoints and functional assessments: objective, quantitative measures that replace subjective clinical observation, built for the rigor that regulatory review demands. Build them yourself in LABO, our no-code platform, or have our team build a custom solution around your protocol.
The problem with subjective clinical assessment
Many clinical outcome measures still rely on a clinician's direct observation: watching a patient perform a task and judging how well they did. That judgment varies from one clinician, site, and visit to the next, and can be hard to defend under the scrutiny a digital endpoint needs to withstand for regulatory review. We help therapeutics teams replace clinician observation with objective, structured, repeatable functional assessments that capture digital endpoints directly.
Subjective assessment
A functional assessment built with SilicoLabs
A clinician's judgment of how well the patient performed
Behavior captured directly: eye, hand, and body movement, timing, accuracy
Hard to reproduce across sites, visits, and patients
The same task, run the same way, every time
Hard to defend under regulatory scrutiny
Quantitative data, built for the rigor review demands
How we build a digital endpoint
There are two ways in. Your team can design a real-world task in LABO's no-code builder and run it yourselves. Or, if you want something built quickly and efficiently, or don't have staff to build it in-house, our team can build a custom solution around your protocol.
Either way, the assessment captures synchronized behavioral data as a patient performs it (eye, hand, and body movement, timing, accuracy, and more) and runs the same way across sites, visits, and patients.
Real examples
Digital endpoints across conditions
Epilepsy
What: Researchers use LABO to study how the brain encodes spatial navigation and consolidates memory in patients with epilepsy, recording continuously over several days as patients complete wayfinding tasks during a hospital stay.
Why it matters: Continuous, real-world data like this shows clinicians how a seizure disorder or its treatment affects a patient's memory and navigation over time, insight a single clinic visit can't capture.
Depression
What: Researchers use LABO to build social-stress scenarios with reactive virtual avatars, studying how adolescents with depression respond to social pressure in a controlled, repeatable environment.
Why it matters: Measuring how a patient actually behaves under stress, not just how they report feeling, gives a clearer signal of whether a treatment is changing real-world behavior.
Healthy aging
What: Researchers use LABO to study how environment affects memory and performance in older adults, isolating the environmental and social cues that influence cognitive function.
Why it matters: Identifying which real-world conditions support or undermine cognitive performance helps therapies and interventions target what actually extends independent living.
Memory
What: Researchers built virtual environments in LABO (a single room, several identical rooms, or several distinct rooms) to study how crossing a doorway changes people's sense of elapsed time and their memory for the order of events.
Why it matters: Remembering when, and in what order, things happened is central to everyday function. Tasks like this measure it in a realistic setting rather than with a word list on a screen.
All four start the same way: a functional assessment built around the question being asked. The result is a digital endpoint designed to support regulatory review.
You own your data
The data behind every digital endpoint and functional assessment, whether you build it in LABO or we build it for you, belongs to your organization: to analyze, to build on, and to use however your regulatory and research strategy requires.
There's no third-party processing pipeline between you and your raw capture: the data behind every digital endpoint is yours from the start.